A synovectomy trial and the history of early knee synovitis in rheumatoid arthritis
Identifieur interne : 003680 ( Main/Exploration ); précédent : 003679; suivant : 003681A synovectomy trial and the history of early knee synovitis in rheumatoid arthritis
Auteurs : K. A. E. Meijers [Pays-Bas] ; H. A. Valkenburg [Pays-Bas] ; A. Cats [Pays-Bas]Source :
- Rheumatology International [ 0172-8172 ] ; 1983-12-01.
English descriptors
- KwdEn :
- Teeft :
- Arthritis, Basic treatment, Cause loss, Conservative treatment, Conservative treatment programme, Control group, Disease duration, Early knee synovitis, Early synovectomy, Excepta medica, Gold intoxication, Joint space, Knee synovitis, Latter group, Maintenance dosage, Medical treatment, Natural history, Netherlands, Netherlands society, Orthopaedic surgeon, Other groups, Present study, Radiological, Radiological changes, Radiological deterioration, Rheumatoid, Rheumatoid arthritis, Rheumatoid factor, Same pattern, Same time, Small group, Statistical significance, Surgical, Surgical group, Surgical treatment, Synovectomized knees, Synovectomy, Synovectomy group, Synovectomy trial, Synovitis, Synovitis groups, Various groups, Years years.
Abstract
Summary: The results of a randomized synovectomy trial are reported and the history of early knee synovitis in 121 patients with rheumatoid arthritis is described. Conservative treatment (rest in splints, non-steroidal anti-inflammatory drugs and gold or an anti-malaria agent) for 4–5 months led to improvement in 81 of the 121 patients with early knee synovitis. In one-third of these 81 patients, the improvement continued, according to their own and the doctor's opinion, during 5 years of follow-up. Ten of the 22 patients who fulfilled the criteria for the synovectomy trial were operated upon. They showed improvement for 4 years. Over the 5-year period, two-thirds of the group were constantly seropositive or seronegative and in the other third the serology varied, but such that at each assessment 50% of the group were seropositive. Radiologically, all of the patients showed deterioration. The surgical group deteriorated more slowly for the first 2–3 years, but then showed the same pattern as the other groups. The disappearance of the clinical features of synovitis does not mean that radiological deterioration has ceased.
Url:
DOI: 10.1007/BF00541595
Affiliations:
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A. E." last="Meijers">K. A. E. Meijers</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology, University Hospital, Rijnsburgerweg 10, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Valkenburg, H A" sort="Valkenburg, H A" uniqKey="Valkenburg H" first="H. A." last="Valkenburg">H. A. Valkenburg</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University, Postbus 1738, NL-3000 DR, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Cats, A" sort="Cats, A" uniqKey="Cats A" first="A." last="Cats">A. Cats</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology, University Hospital, Rijnsburgerweg 10, NL-2333 AA, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Rheumatology International</title><title level="j" type="sub">Clinical and Experimental Investigations</title><title level="j" type="abbrev">Rheumatol Int</title><idno type="ISSN">0172-8172</idno><idno type="eISSN">1437-160X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1983-12-01">1983-12-01</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="161">161</biblScope><biblScope unit="page" to="166">166</biblScope></imprint><idno type="ISSN">0172-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0172-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Knee synovitis</term><term>Rheumatoid arthritis</term><term>Synovectomy trial</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Arthritis</term><term>Basic treatment</term><term>Cause loss</term><term>Conservative treatment</term><term>Conservative treatment programme</term><term>Control group</term><term>Disease duration</term><term>Early knee synovitis</term><term>Early synovectomy</term><term>Excepta medica</term><term>Gold intoxication</term><term>Joint space</term><term>Knee synovitis</term><term>Latter group</term><term>Maintenance dosage</term><term>Medical treatment</term><term>Natural history</term><term>Netherlands</term><term>Netherlands society</term><term>Orthopaedic surgeon</term><term>Other groups</term><term>Present study</term><term>Radiological</term><term>Radiological changes</term><term>Radiological deterioration</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Rheumatoid factor</term><term>Same pattern</term><term>Same time</term><term>Small group</term><term>Statistical significance</term><term>Surgical</term><term>Surgical group</term><term>Surgical treatment</term><term>Synovectomized knees</term><term>Synovectomy</term><term>Synovectomy group</term><term>Synovectomy trial</term><term>Synovitis</term><term>Synovitis groups</term><term>Various groups</term><term>Years years</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The results of a randomized synovectomy trial are reported and the history of early knee synovitis in 121 patients with rheumatoid arthritis is described. Conservative treatment (rest in splints, non-steroidal anti-inflammatory drugs and gold or an anti-malaria agent) for 4–5 months led to improvement in 81 of the 121 patients with early knee synovitis. In one-third of these 81 patients, the improvement continued, according to their own and the doctor's opinion, during 5 years of follow-up. Ten of the 22 patients who fulfilled the criteria for the synovectomy trial were operated upon. They showed improvement for 4 years. Over the 5-year period, two-thirds of the group were constantly seropositive or seronegative and in the other third the serology varied, but such that at each assessment 50% of the group were seropositive. Radiologically, all of the patients showed deterioration. The surgical group deteriorated more slowly for the first 2–3 years, but then showed the same pattern as the other groups. The disappearance of the clinical features of synovitis does not mean that radiological deterioration has ceased.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Leyde</li><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Meijers, K A E" sort="Meijers, K A E" uniqKey="Meijers K" first="K. A. E." last="Meijers">K. A. E. Meijers</name></region><name sortKey="Cats, A" sort="Cats, A" uniqKey="Cats A" first="A." last="Cats">A. Cats</name><name sortKey="Valkenburg, H A" sort="Valkenburg, H A" uniqKey="Valkenburg H" first="H. A." last="Valkenburg">H. A. Valkenburg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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